Hi Sainter, welcome to the site. The connection to your Hot Rod Deluxe should be simple enough. Just plug the 'Send' from the amp into the input of the ME20 and the 'Return' from the amp into the output(left/mono) of the ME20. I'm not familiar with the ME20, but possibly there may be a setting that allows you to change its output for use in an EFX loop. I have an old GT6 that allows for this. You'll find that delays and reverbs work well in this configuration, but overdrives and distortions may not. This is because the effects loop usually is just a serial break between the preamp stage and the power amp stage of an amp. Sometimes an effects loop is parallel, but all this means is you have more control over how much of the effects in the effects loop affect the overall sound, because they are being mixed with the regular amp electronics.
If you're familiar with mixing desks, you can think of the two types of effects loops as 'inserts' (series, as found on most amps) or auxiliary send/return points (parallel loops).
Please let me know how you went!
